Cambridge Biomedical Campus (DISC), UK
Salary: Competitive with Excellent Employee Benefits
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.
Are you a scientist who wants to apply your knowledge of cell culture and hands-on biological assay experience into a dedicated Research & Development team at AstraZeneca, Are you fuelled by the commitment to help more patients, strengthen our pipeline and grow our therapeutic areas, Are you a dynamic and highly motivated lab based scientist that can support our expanding RNA drug pipeline?
Be part of the Bioassay, Biosafety and Impurities Group accountable for developing pioneering methods to evaluate product quality by measuring biological activity and detecting, characterizing, and quantifying product variants and process-related impurities for biologics (e.g., monoclonal antibodies, RNAs, modified peptides, viruses etc). This enables product understanding, manufacturing process development, formulation, drug product development and regulatory filings to bring our drugs to the clinic and eventually onto the market.
AZ Cambridge
An exciting Life Science hotspot, Cambridge is home to one of AstraZeneca’s three strategic, global R&D Centres, alongside Gothenburg and Gaithersburg. Over 3,600 employees work from our various sites across Cambridge and our offices are internationally renowned for attracting exceptional talent.
The Discovery Centre (DISC), located at the heart of the Cambridge Biomedical Campus, is designed to play a central role in our mission to deliver life-changing medicines to patients. As our largest research and development centre in the UK, it will have more than 2,000 people working across therapy areas and drug discovery and development once fully occupied.
Find out more about our Cambridge campus and the DISC, here: https://www.astrazeneca.com/our-company/our-locations/cambridge.html
What you will do:
Develop potency and characterisation bioassays based on drug mode of action with a focus on RNA and RNA – lipid nanoparticle (LNP) products (e.g., mRNAs) using techniques like cell transfection followed by immunoassays to quantify levels and examine functionality of the transgene protein products
Enable transfer of any developed methods to other groups as appropriate
Carry out routine sample testing to feed into product development CMC activities
Convert opportunities and resources to succeed and thrive around the team and communicate achievements to different audiences, including at team meetings, global group meetings and in matrix teams
Learn from experience and guidelines/documentation to increase responsibilities and complexity of tasks to be performed with a higher level of autonomy
Essential:
Minimum BSc (or equivalent) in Cell Biology, Virology, Immunology, Cellular Biochemistry, or related field together with relevant professional/academic experience
Familiarity and extensive hands-on experience with mammalian cell culture and in-depth experience with immunoassay techniques, e.g., ELISA, DELFIA, HTRF
Optimisation of experimental protocols for biological assays (e.g., cell-based immunoassays) to control quality of results supporting drug development decisions
Good time management skills, ability to flex and handle multiple responsibilities and tasks on a regular basis
Desired:
Comprehensive experience in cellular delivery of RNAs and RNA:LNPs
Small scale RNA synthesis (IVT), LNP formulation and basic RNA analytics
Drug development experience in Pharma/Biotech industry
Scientific background in virology, immunology or vaccines
Why AstraZeneca!
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial -finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering ground-breaking methods and bringing unexpected teams together. Interested? Come and join our journey.
So, what’s next!
Are you already imagining yourself joining our team, because we can’t wait to hear from you.
Where can I find out more
Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
Follow AstraZeneca on Facebook - https://www.facebook.com/astrazenecacareers/
Follow AstraZeneca on Instagram - https://www.instagram.com/astrazeneca_careers/?hl=en
Job Posted: 09/08/2023